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解码人类的产前免疫系统与单细胞多omics

Muzlifah Haniffa1,2,3,4, Aidan Maartens5, Elena Winheim5

  • 1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. mh32@sanger.ac.uk.

Nature reviews. Immunology
|November 1, 2024
PubMed
概括

了解人类免疫系统的发展是关键. 新的基因组技术正在揭示复杂的时间,细胞类型和环境,这些都对从产前阶段开始构建这种复杂的防御网络至关重要.

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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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