休时间的体力活动和生物衰老在2型糖尿病中的剂量反应:一个横截面研究
Dongzhe Wu1, Yishuai Jia2, Yujia Liu3
1Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Scientific reports
|November 1, 2024
概括
定期的休时间体育活动 (LTPA) 显著减少了2型糖尿病 (T2D) 患者的生物衰老. 适度的活动水平显示了最大的益处,突出了个性化炼计划的必要性,以促进健康的衰老.
科学领域:
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2D) 与加速的生物衰老有关.
- 休时间的体力活动 (LTPA) 可能在缓解这个衰老过程中发挥作用.
- 了解LTPA模式对于管理T2D群体的健康至关重要.
研究的目的:
- 检查不同LTPA模式与T2D成年人的表型衰老加速 (PhenoAgeAccel) 之间的关联.
- 确定LTPA对生物衰老的影响的潜在非线性关系和值.
- 为促进T2D患者健康衰老的公共卫生策略提供信息.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) (1999-2018) 中4,134名2型糖尿病成年人的数据.
- 采用多变量线性回归和限制立方线 (RCS) 模型来分析LTPA和PhenoAgeAccel.
- 应用分段概率测试和分层回归用于值和相互作用分析.
主要成果:
- 定期的LTPA模式与较低的PhenoAgeAccel分数 (β = -1.164,P < 0.0001) 有显著的关联.
- 观察到非线性值效应;每周LTPA低于594.57分钟显示出显著的负相关性 (β = -0.002,P = 0.000).
- "周末战士"和"不活跃-LTPA"模式没有显著影响;注意到性别特异性差异.
结论:
- 定期的LTPA有效地减少了T2D患者的表型衰老加速.
- 适度的体力活动水平似乎是最有益的,与非线性剂量反应关系.
- 研究结果支持个性化体育活动指南和公共卫生倡议,以促进T2D患者健康老龄化.
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