波利亚可可斯:传统用途,三类成分及其保护性药理学
Zhi-Yuan Guo1, Xin Wu1, Shui-Juan Zhang1
1School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Acta pharmacologica Sinica
|November 1, 2024
概括
波里亚可可斯及其表面层富含三类化合物,具有显著的利尿和保护作用. 这些天然化合物在治疗各种脏疾病和预防纤维化方面表现有前途.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- (Polyporaceae) 和它的表面层在传统中医中被用于利尿和保护性质.
- 四环三类化合物,包括兰和3,4-二次兰衍生物,是Poria cocos及其表面层中的主要植物化学物质.
- 有证据表明,这些三类化合物对Poria cocos的脏保护作用负责.
研究的目的:
- 研究Poria cocos及其表面层的利尿和保护作用.
- 探索Poria cocos triterpenoids的脏保护作用背后的分子机制.
- 在各种脏疾病模型中评估Poria cocos提取物的疗效.
主要方法:
- 植物化学分析以确定关键的三类成分.
- 对 Poria cocos 与其表面层的利尿作用的比较研究.
- 在急性损伤,慢性病 (包括糖尿病病,性综合征,管介质病) 和纤维化模型中,从表面层中评估乙醇提取物.
- 研究分子通路,包括TGF-β1/Smad,Wnt/β-catenin,IκB/NF-κB,Keap1/Nrf2,renin-angiotensin系统,矩阵金属蛋白酶,aryl碳化合物受体和内源代谢物.
主要成果:
- 与整个Poria cocos相比,Poria cocos的表面层表现出更强大的利尿作用.
- 表面层的乙醇提取物及其分离成分在改善急性损伤,从急性病过渡到慢性病以及确定的慢性病等疾病方面表现出有效性.
- 观察到对纤维化的保护,阐明了涉及关键信号通路和生物系统调节的机制.
结论:
- 波里亚子及其表面层具有显著的利尿和脏保护性质,主要归因于它们的三类成分.
- 表面层显示出增强的利尿活性和各种脏疾病的更广泛的治疗潜力.
- 确定的分子机制为Poria cocos在治疗脏疾病中的传统用途提供了科学依据,并支持其临床应用的潜力.
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