巨细胞动脉炎的非典型迹象和症状:系统性审查
Irina Sverdlichenko1, Jim Shenchu Xie2, Brianna Lu1
1Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Journal of general internal medicine
|November 1, 2024
概括
巨细胞动脉炎 (GCA) 的非典型症状可能会延迟诊断和治疗. 早期识别这些不寻常的迹象对于及时干预和预防严重并发症至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 内部医学 内部医学
- 血管医学 血管医学
背景情况:
- 巨细胞动脉炎 (GCA) 可以呈现出多样化,有时不寻常的症状.
- 由于非典型的表现而延迟诊断GCA会增加严重并发症的风险.
研究的目的:
- 系统地审查和描述与活检证明的巨细胞动脉炎相关的所有非典型症状和症状.
- 为了比较典型与非典型的GCA特征的患者之间的治疗时间表和治疗结果.
主要方法:
- 进行了对MEDLINE,Embase和Cochrane控制试验中央注册表的系统审查.
- 包括的研究中,至少有一名参与者具有活检证明的非典型GCA标志/症状.
- 数据提取和查是重复执行的,重点关注非典型特征和治疗时间.
主要成果:
- 分析了429项涉及746名具有非典型GCA特征的个体的研究.
- 18%的非典型GCA特征患者仅表现出这些不寻常的症状.
- 常见的非典型症状包括头,头皮亡和干咳,仅在具有非典型特征的患者中观察到延迟治疗.
结论:
- 具有非典型特征的GCA病例中很大一部分可能没有典型症状,导致治疗延迟.
- 对非典型的GCA表现的认识对于及时诊断和管理至关重要.
- 建议进行早期炎症标志物测试,以预防与GCA相关的发病率.
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