乳腺癌治疗后的心血管疾病风险在患有BRCA1/2致病变体的患者中
Lara Terra1, Naomi B Boekel1, Maartje H Hooning2
1Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, Amsterdam, CX, The Netherlands.
这项研究发现,与其他乳腺癌患者相比,患有BRCA1/2致病变体 (BRCA1/2pv) 的女性乳腺癌患者在治疗后患心血管疾病 (CVD) 的风险并不高.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
背景情况:
- 乳腺癌 (BC) 治疗可能导致心血管疾病 (CVD).
- 在BRCA1/2病原型 (BRCA1/2pv) 携带者中,缺陷的DNA修复可能会增加心血管疾病的风险.
- 在BRCA1/2pv携带者中,心血管疾病后BC治疗的差异风险尚未得到充分确立.
研究的目的:
- 调查女性BRCA1/2pv携带者在BC治疗后是否比没有已知的BRCA1/2pv的BC患者更容易患心血管疾病.
主要方法:
- 一项基于医院的队列研究包括17300名女性BC患者,其中509人被确定为BRCA1/2pv携带者.
- 心血管疾病发病率和死亡率通过医疗记录和问卷进行评估.
- 考克斯回归分析比较了BRCA1/2pv携带者和其他BC患者之间的心血管疾病风险,并对共变量进行了调整.
主要成果:
- 在14年的中位数随访期间,BRCA1/2pv携带者表现出非显著的趋势,导致缺血性心脏病 (IHD) 风险增加 (adjHR 1.51),但没有心力衰竭 (HF) (adjHR 0.86).
- 放射治疗与IHD风险的关联在携带者和非携带者之间没有显著差异.
- 同样,在BRCA1 / 2pv携带者和其他BC患者中,基于antracycline的化疗和HF风险关联是可比的.
结论:
- 在患有BRCA1/2致病变体的乳腺癌患者中,与其他乳腺癌患者相比,没有证据表明与治疗相关的心血管疾病的风险增加.
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