不孕症治疗和乳腺良性疾病的风险:一个病例控制研究
Ashraf Moini1,2,3, Sadaf Alipour3,4, Zahra Zandi5,6
1Endocrinology and Female Infertility Unit, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
BMC women's health
|November 1, 2024
概括
这项研究发现,在不育妇女中,诸如排卵诱导 (OI),辅助生殖技术 (ART) 和良性乳腺疾病 (BBD) 等不育治疗方法之间没有联系. 由于样本规模较小,需要进一步研究.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 妇女健康 妇女健康
背景情况:
- 在不孕症治疗期间内分泌的波动理论上可能会增加良性乳腺疾病 (BBD) 的风险.
- 之前没有研究研究过不孕症治疗和BBD之间的关联.
- 本研究通过检查各种不孕症治疗和BBDs之间的关系来解决这个差距.
研究的目的:
- 调查不孕症治疗与不孕妇女良性乳腺疾病 (BBD) 风险之间的关联.
- 为了确定排卵诱导 (OI) 或辅助生殖技术 (ART) 是否与BBD相关.
- 分析治疗类型,持续时间和数量对BBD风险的影响.
主要方法:
- 研究人员对154名不育妇女进行了病例对照研究 (50例有BBD,104例没有BBD).
- 在影像查 (乳房影像/超声波) 后,通过组织病理学证实了BBD诊断.
- 关于不孕症治疗的数据是从医疗记录和问卷中追溯收集的.
主要成果:
- 在BBD风险和以前的不孕症治疗 (OR=1.21),ART (OR=1.14) 或OI周期 (OR=1.13) 之间没有发现显著的关联.
- 66%的病例和61.4%的对照人至少接受过一次不孕不育治疗.
- 通过混变量进行分层并没有改变观察到的缺乏关联.
结论:
- 目前的研究结果表明,不孕不育妇女的BBD与先前不孕不育治疗的类型,持续时间或数量之间没有联系.
- 样本规模小,因此在解释这些结果时需要谨慎;不应忽视临床意义.
- 更大规模的前性研究对于进一步阐明BBD与特定不孕症治疗或药物之间的潜在关联至关重要.
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