在主观认知衰退中补充类:一个36周的随机,安慰剂对照试验的结果
Samantha Galluzzi1, Moira Marizzoni2, Elena Gatti1
1Laboratory Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, Italy.
Nutrition journal
|November 1, 2024
概括
这项研究发现,果皮提取物与安慰剂相比,在主观认知衰退 (SCD) 患者中没有改善认知功能. 较高的安慰剂反应可能影响了结果,影响了SCD的未来营养药试验设计.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 主观认知衰退 (SCD) 影响老年人,可能是痴呆症的先兆.
- 类植物化学物质显示出对认知和炎症的临床前承诺.
- 在认知健康中,类衍生化合物的临床证据有限.
研究的目的:
- 调查果皮提取物补充剂对SCD患者认知表现的长期影响.
- 评估果皮提取物对炎症标志物的影响,特别是介质蛋白-8 (IL-8).
主要方法:
- 80名患有SCD的参与者被随机分配给接受树皮提取物或安慰剂36周.
- 认知功能使用可重复电池评估神经心理状态 (RBANS) 和其他认知测试进行评估.
- 测量了interleukin-8 (IL-8) 水平作为一个次要的结果在一个子样本.
主要成果:
- 这两组在36周的时间里,RBANS总分和口头记忆都有显著的改善.
- 在果皮提取物和安慰剂组之间没有观察到认知改善的显著差异.
- 两组人群中,白血素-8 (IL-8) 的水平都增加,治疗方法之间没有显著差异.
结论:
- 在SCD患者中,长期服用树皮提取物补充剂并没有显示比安慰剂有认知益处.
- 实质性的安慰剂效应可能有助于两组观察到的认知改善.
- 研究结果表明,在设计未来SCD营养药试验时,要仔细考虑安慰剂反应.
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