通过外生体调节内皮质-介质酶转换的进展
Sun Sishuai1, Gu Lingui1, Li Pengtao1
1Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Stem cell research & therapy
|November 1, 2024
概括
外体细胞调节内皮质-介质细胞转化 (EndoMT),这是与疾病相关的过程. 来自干细胞的外体细胞在抑制EndoMT方面表现有前途,为血管疾病提供治疗潜力.
科学领域:
- 细胞生物学 细胞生物学
- 生物医学工程 生物医学工程
- 血管生物学 血管生物学
背景情况:
- 内皮-介质细胞转化 (EndoMT) 涉及内皮细胞转化为介质细胞,影响形态,基因表达和功能.
- EndoMT被认为是心血管疾病,脑血管疾病,瘤转移和纤维化的危险因素.
- 外基因组对于细胞间通信至关重要,在调节EndoMT方面发挥着重要作用.
研究的目的:
- 在各种疾病背景下系统地审查外体在调节EndoMT中的作用.
- 探索基于外体的干预策略,以抑制EndoMT.
主要方法:
- 对研究EndoMT外体介导调节的研究进行文献综述.
- 对外体细胞的起源 (患病者与干细胞/原生细胞) 的分析及其对EndoMT的影响.
- 对治疗应用的外体细胞修饰策略的评估.
主要成果:
- 来自病态环境的外体可以促进EndoMT,增加内皮透气性并损害血管完整性.
- 来自干细胞或原生细胞的外体体表现出对EndoMT的抑制作用,保持内皮功能.
- 外体修饰提供了针对性传递和增强EndoMT抑制的潜力.
结论:
- 外基因组是EndoMT的关键调节者,与疾病相关的外基因组促进了这一过程,而干细胞衍生的外基因组抑制了这一过程.
- 对外体的有针对性修改为控制EndoMT和减轻相关疾病提供了一个有希望的治疗策略.
- 对基于外体的治疗方法的进一步研究可能会导致针对血管病理和纤维化的新治疗方法.
更多相关视频
07:05TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
Published on: February 26, 2021
5.1K
07:03Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
2.0K
相关概念视频
Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
