在急性和慢性尼古丁治疗后,情境恐惧条件和灭绝的性别差异
Jack V Keady1, Marissa C Hessing1, Judy C Songrady1
1Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, 789 S. Limestone Street, 473 Lee T. Todd Jr. Building, Lexington, KY, 40536-0596, USA.
Biology of sex differences
|November 1, 2024
概括
尼古丁戒断损害了雌性小鼠的恐惧灭绝学习,这与特定性别的海马体基因表达变化有关. 这突出了吸烟者认知缺陷的潜在生物媒介.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 慢性吸烟会导致戒烟症状,包括认知缺陷.
- 报告了尼古丁戒断症状的性别特异性差异,但根本的生物机制尚未完全理解.
- 在尼古丁戒断期间,上下文恐惧记忆,一种依赖海马的认知功能,受到干扰.
研究的目的:
- 研究尼古丁和戒断对情境恐惧记忆的性别特异性影响.
- 探索尼古丁戒断期间性别特异性认知缺陷背后的生物媒介.
主要方法:
- 雄性和雌性小鼠接受了急性或慢性尼古丁或盐水治疗.
- 进行了情境恐惧调节和灭绝试验.
- 在海马中分析了尼古丁乙胆受体水平,基因表达 (fosb,cfos,bdnf,erbb4).
主要成果:
- 雌性小鼠表现出比雄性更强的情境恐惧记忆.
- 只有男性的急性尼古丁增强恐惧记忆.
- 尼古丁戒断影响了女性的灭绝学习,但男性没有.
- 尼古丁戒断在两性中同样抑制了海马的fosb,cfos和bdnf.
- 腹腔海马erbb4表达在两性中都在戒断后升高.
结论:
- 海马回路中的性别特异性功能障碍可能是尼古丁戒断期间灭绝学习中的女性特异性缺陷的基础.
- 腹部海马基因表达 (fosb,cfos,bdnf,erbb4) 预测女性的灭绝学习受损.
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