阿姆洛迪平增加了原发性开角玻璃眼的风险
Steven Lehrer1, Peter H Rheinstein2
1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. steven.lehrer@mssm.edu.
Clinical hypertension
|November 1, 2024
概括
阿姆洛迪平是一种常见的高血压药物,与初级开角玻璃眼 (POAG) 的更高风险有关. 替代药物,如利尿剂和β抑制剂,可能对高危患者更安全.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 遗传学 是一个遗传学.
背景情况:
- 通道阻塞剂在统计学上与原发性开角玻璃眼 (POAG) 有关.
- 之前的研究表明,使用通道阻塞剂的使用者中,POAG风险增加了23%.
- 这种关联的遗传基础仍未得到研究.
研究的目的:
- 为了确认amlodipine和POAG之间的关联.
- 研究特定的POAG相关基因在这种关系中的作用.
- 评估阿姆洛迪平对眼内压力 (IOP) 的影响.
主要方法:
- 利用MedWatch和英国生物库的数据来评估amlodipine对POAG和IOP的影响.
- 分析了三个与POAG相关的单核酸多态 (SNP):rs9913911 (GAS7),rs944801 (CDKN2B-AS1) 和rs2093210 (SIX6).
- 在数据分析中使用多变量逻辑回归.
主要成果:
- 阿姆洛迪平的使用与POAG患病率显著增加有关 (在MedWatch数据中为0.0805%至0.177%).
- 英国生物库的分析显示,随着年龄,男性性别,GAS7和CDKN2B-AS1的特定等位基因以及SIX6.6.的POAG风险增加.
- 阿姆洛迪平的使用增加了POAG风险16.1% (P=0.032) 但与升高的内血压无关.
- CDKN2B-AS1和SIX6,POAG基因与IOP无关,与POAG和阿姆洛迪平相关.
结论:
- 阿姆洛迪平是一种一线抗高血压药,具有POAG发展的潜在风险.
- 这一发现表明,应考虑替代性抗高血压药物治疗青光眼患者或有风险的患者.
- 利尿剂和β抑制剂是可行的替代品,因为它们与POAG或增加的内压无关.
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