患有鼻炎的患者的MUC5AC表达:系统性审查和元分析
1Department of Otolaryngology Head and Neck Surgery, First Hospital of Hainan Medical College, Haikou, China.
Clinical and translational allergy
|November 1, 2024
概括
增加MUC5AC表达显著与鼻炎风险增加有关,包括带有鼻和没有鼻的慢性鼻炎. 这表明MUC5AC可能成为用于鼻炎诊断和管理的有价值的生物标志物.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物标志物发现发现
- 粘膜免疫学 粘膜免疫学
背景情况:
- 鼻炎是一种常见的疾病,具有复杂的病理生理学.
- 一种主要的凝形成粘素Muc5AC,在气道防御中起作用.
- 了解Muc5AC的作用可能提供诊断和治疗见解.
研究的目的:
- 调查Muc5AC表达与鼻炎之间的关联.
- 评估Muc5AC作为鼻炎生物标志物的潜力.
主要方法:
- 进行了系统的文献综述和元分析.
- 在多个数据库 (PubMed,Embase,Cochrane,CNKI,Wanfang) 搜索到2023年11月.
- 分析了来自16项涉及1448名使用STATA 14.0.0的患者的研究数据.
主要成果:
- 与对照组相比,患有带鼻息肉的慢性鼻炎 (CRSwNP) 和没有鼻息肉的慢性鼻炎 (CRSsNP) 的患者的Muc5AC表达显著上调.
- 免疫组织化学证实CRSwNP和CRSsNP患者组中MUC5AC水平升高.
- 根据组织类型 (鼻液,鼻腔粘膜) 的子组分析支持了总体发现.
结论:
- 这一元分析证实了Muc5AC表达升高与鼻炎之间存在显著的关联.
- Muc5AC显示出作为鼻炎的分子标记物的潜力.
- 这些发现支持对Muc5AC进行进一步的研究,用于治疗鼻炎管理中的治疗干预措施.
相关概念视频
01:23Chronic Pharyngitis
1.3K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
1.3K
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
233
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
233