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Updated: Jun 9, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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氨酸脱乙酶抑制剂在细胞中具有较低的选择性,并且主要表现出非目标效应

Kiara E Bornes1, Marcus A Moody2, Thomas M Huckaba3

  • 1Department of Chemistry, Xavier University of Louisiana, New Orleans, LA, USA.

FEBS open bio
|November 1, 2024
PubMed
概括

氨酸脱乙酶 (KDAC) 抑制剂显示出显著的脱效应,而不是预期的KDAC抑制. 基因失活揭示了真正的生物学作用,为KDAC6抑制剂提出了新的治疗策略.

关键词:
在 HDAC6 中.在 HDAC8 中,HDAC8 是这就是HDACi.在RNA-seqq.免疫光效应 免疫光效应

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