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短链脂肪酸可以通过激活mTOR信号通路来增强肌肉质量和功能,这种作用发生在肉性小鼠身上

Chaoran Liu¹, Pui Yan Wong¹, Qianjin Wang¹

¹Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China.

Journal of cachexia, sarcopenia and muscle

|November 1, 2024

概括

短链脂肪酸 (SCFA) 补充剂在老年小鼠中改善了肌肉质量和功能. 这项研究表明,SCFA可以通过调节肠道健康和肌肉通路来对抗肉类的治疗策略.

科学领域:

老年学是一门学科.
微生物学微生物学
肌肉生理学肌肉生理学

背景情况:

萨科佩尼亚是老年人常见的肌肉疾病,与增加的死亡率和骨折有关.
在患有肉症的老年人中观察到有益的肠道微生物代谢物,短链脂肪酸 (SCFA) 的水平降低.
调查SCFAs作为潜在的治疗干预萨尔科佩尼亚是合理的.

研究的目的:

确定SCFA补充是否可以作为与年龄相关的肌肉损失和功能障碍的治疗策略.
在sarcopenia的临床前模型中研究SCFA对肠道微生物群,肠道屏障功能和炎症的影响.
阐明分子途径,包括mTOR信号传递,参与SCFA介导的肌肉改善.

主要方法:

七个月大的老化加速小鼠易患8 (SAMP8) 类小鼠,是肉症的一个模型,在三个月内每天接受SCFA尾酒治疗.
用16S rDNA测序分析了肠道微生物组成.
使用各种生化和分子技术评估肌肉质量,功能,肠道透性 (脂聚糖水平),结肠炎症和相关信号通路 (例如mTOR).
使用C2C12神经管进行了体外研究,以进一步调查mTOR信号传递的作用.

主要成果:

与对照组相比,SCFA补充剂在老年SAMP8小鼠中导致肌肉质量,肌肉纤维大小,握力和肌肉功能显著改善.
用SCFA治疗逆转了肠道炎症,并改善了SAMP8小鼠的肠道屏障完整性.
此外,SCFA增强了抗疲劳能力和肌肉糖原储存,同时促进线粒体生物发生和减弱脂肪透到缩肌肉中.
分子分析显示,SCFA调节AMPK和mTOR信号通路,影响蛋白质合成和肌肉生长.

结论:

细菌代谢物,SCFA,可以有效地减轻与年龄有关的肌肉损失和功能障碍.
通过改善肠道健康和肌肉新陈代谢,SCFA补充剂显示出作为治疗的治疗方法的希望.
与蛋白质合成相关的mTOR信号通路在SCFA对肌肉健康的有益影响中起着至关重要的作用,无论是体内还是体外.

关键词:

衰老的衰老衰老的衰老我们的肠道微生物群.肌肉肌肉肌肉肌肉萨尔科佩尼亚是什么意思萨尔科佩尼亚短链脂肪酸短链脂肪酸短链脂肪酸

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