作为新型药物输送系统的Bigels:对效率和影响因素的系统审查
Shahrzad Shakouri1, Mostafa Mazaheri Tehrani1, Arash Koocheki1
1Department of Food Science and Technology, Ferdowsi University of Mashhad (FUM), Mashhad, Iran.
Current reviews in clinical and experimental pharmacology
|November 1, 2024
概括
比格尔,一种新的双相配方,有效释放活性剂. 这次审查强调了它们在药物输送方面的潜力,许多研究中观察到的释放率超过90%.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 比格尔是创新的配方,结合了水凝和有机凝阶段.
- 这种双重性质允许控制释放水友和脂友活性剂.
- 它们为各种应用提供独特的物理化学和质性质.
研究的目的:
- 在药物释放应用中系统地审查和评估大饼的效率.
- 为了识别在Bigel配方和药物释放中常见的材料和有影响的因素.
主要方法:
- 在PubMed,Scopus和ISI Web of Science进行了系统的文献搜索.
- 包括20篇符合预先定义的标准的文章进行分析.
- 提取和合成了关于比格尔成分,药物释放和影响因素的数据.
主要成果:
- 天然材料,如Span和向日油经常用于机体凝组件,而生物聚合物,如凝和 agar形成了水凝阶段.
- 甲尼达是从大牛肉中释放的最受研究的药物.
- 药物释放率差异很大,在42.85%的审查研究中实现了90%以上的释放.
- 影响大形成和药物释放的关键因素包括凝阶段的特性和温度和混合速度等过程变量.
结论:
- 比格尔是药物输送的一个有前途的平台,为控制释放提供可调节的特性.
- 它们的优良生物相容性和证明的体外/体外疗效支持它们的工业和治疗潜力.
- 为最大限度地提高治疗效果和确保一致的性能,优化大贝制备方法至关重要.
相关概念视频
01:16Drug Delivery: Overview
278
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
278
01:18Drug Delivery: Enteral Route
384
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
384
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
121
01:22Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
01:23Factors Influencing Bioavailability: First-Pass Elimination
6.2K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
6.2K
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
178
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
178