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主体特异性和局部分离的多菌株益生菌对小猪的表现,死亡率,炎症反应和肠道微生物群的影响

Katatikarn Sahatsanon¹, Panneepa Sivapirunthep², Korawan Sringarm³

¹Doctoral Program in Innovative Tropical Agriculture, Department of Agricultural Education, School of Industrial Education and Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Animal bioscience

|November 1, 2024

概括

多菌株益生菌 (MLAB) 没有改善小猪生长,但增强了免疫功能和肠道健康. 这表明,MLAB补充剂可以促进更健康的肠道微生物群,并可能降低小猪死亡率.

科学领域:

动物科学动物科学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

小猪的死亡率和不理想的肠道健康状况在猪生产中构成重大挑战.
保持平衡的肠道微生物组对于小猪的健康和表现至关重要.
益生菌提供了一个潜在的策略来调节肠道环境和免疫反应.

研究的目的:

评估特定多菌株益生菌 (MLAB) 对小猪表现,死亡率和免疫状况的影响.
分析MLAB对小猪肠道微生物社区结构的影响.
确定MLAB在改善肠道健康和降低断奶小猪的死亡率方面的潜力.

主要方法:

一项受控研究涉及52个小猪 (Landrace和大白品种),分为对照组和MLAB组.
从7天开始口服MLAB,直到断奶 (4周),然后在断奶后4周补充料.
评估小猪的表现,死亡率,炎症性细胞因子表达 (IL-4,IL-10) 和肠道微生物组组成 (多样性,丰富性,类,属).

主要成果:

补充MLAB并没有显著改变小猪生长表现,但显示出降低死亡率的趋势 (p=0.06).
MLAB上调了抗炎细胞因子IL-4和IL-10 (p<0.05),并增加了微生物多样性 (辛普森指数:p=0.06) 和丰富性 (Chao1指数:p=0.02).
MLAB增加了Firmicutes的丰度 (p<0.01) 和减少了Bacteroidota (p<0.01),减少了Prevotellaceae_NK3B31和克拉米迪亚属.

结论:

补充MLAB可以通过上调抗炎细胞因子来积极影响小猪的免疫功能.
MLAB促进了更健康的肠道微生物群组成,其特点是多样性增加和细菌群的有利转变.
虽然没有直接影响生长,但MLAB显示了通过免疫和肠道调节改善小猪整体健康和降低死亡率的潜力.

关键词:

乳杆菌菌种类. 乳杆菌种类.微生物社区微生物社区支持炎症的细胞因子断奶的猪断奶的猪是什么意思

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