在中国,对一种高毒性III组猪甲状病毒的隔离和致病性
Yu Wu1,2, Xiaopeng Gao1,3, Zhanpeng Kuang2
1Wen's Group Academy, Wen's Foodstuffs Group Co., Ltd., Xinxing, Guangdong, China.
Frontiers in cellular and infection microbiology
|November 1, 2024
概括
一种新的Getah病毒 (GETV) 菌株导致幼猪严重生病和死亡. 在孕母猪中,GETV诱导病毒性病,影响生育性能和减少小猪的存活率,突出其对养猪的威胁.
科学领域:
- 兽医病毒学 兽医病毒学
- 动物病理学 动物病理学
背景情况:
- 盖塔病毒 (GETV) 是一种影响猪的多宿主病原体,由于发烧,腹和生殖问题,在养猪业造成重大经济损失.
- 在不同年龄组的猪中对GETV的致病性存在有限的研究.
研究的目的:
- 从患病的猪中分离和鉴定一种新的GETV菌株.
- 为了研究这种新菌株在不同年龄的小猪和孕母猪中的病原性.
主要方法:
- 从临床受影响的猪中分离出一种新的GETV菌株 (GETV-QJ).
- 全基因组测序用于遗传学分析.
- 在7天大的小猪和孕母猪中进行实验性感染研究.
主要成果:
- 隔离的GETV-QJ菌株属于III组,与其他亚型具有很高的同质性.
- 在7天大的小猪中,该菌株导致严重的腹,发烧,肠道和肺部损伤,导致100%的死亡率.
- 孕母猪经历了病毒病和降低产卵性能,但没有发烧,死亡或流产.
结论:
- 一种高度毒性的III组GETV菌株被隔离和鉴定.
- 在小猪和母猪中建立了GETV的致病模型.
- 研究结果为预防和控制猪群GETV感染提供了关键的见解.
更多相关视频
相关概念视频
Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
Plague
Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...
Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...


