宁夏的猪衍生菌Enterococcus hirae调节炎症功能,并增强猪仔对ETEC挑战的保护
Longlin Zhang1,2, Zichen Wu1,2, Zihao Zhang1
1College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China.
Frontiers in cellular and infection microbiology
|November 1, 2024
概括
补充Enterococcus hirae (Eh) 改善了小猪的生长,并减少了ETEC感染引起的腹. 增强免疫力和肠道健康,可能通过酸盐生产,有利于小猪的健康.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠毒性大肠杆菌 (ETEC) 感染会对小猪生长和健康产生负面影响.
- ETEC挑战导致料摄入量减少,腹增加和炎症反应加剧.
- 了解对ETEC的保护策略对于生猪生产至关重要.
研究的目的:
- 评估宁夏猪*Enterococcus hirae* (Eh) 在减轻小猪体内ETEC诱导作用方面的疗效.
- 研究Eh对小猪生长,腹和免疫反应的影响.
- 探索短链脂肪酸 (SCFA),炎症和EH的保护机制之间的关系.
主要方法:
- 猪仔被挑战使用ETEC,其中一些猪仔接受口服*Enterococcus hirae* (Eh) 补充剂.
- 监测了生长表现 (ADG,ADFI),腹发病率,直肠温度和指数.
- 分析了炎症性细胞因子的表达和血清sIgA和结肠SCFA的水平.
主要成果:
- ETEC感染显著减少了生长,增加了腹 (24%),并增加了炎症标志物.
- 补充剂改善了料摄入量,减少了腹率 (11.53%),并减少了炎症.
- 乙酸盐水平与炎症性细胞因子有负相关性,这表明它具有关键的抗炎作用.
结论:
- *Enterococcus hirae*有效地保护小猪免受ETEC K88挑战,改善生长并减少腹.
- 它调节免疫反应和肠道健康,可能通过肠-酸盐-脏轴.
- Eh代表了一种有前途的益生菌策略,可以提高小猪的健康和表现.
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