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鼻和鼻癌患者的神经认知功能,这些患者接受多模式疗法治疗
Dan Yaniv1, Lindsay M Niccolai2, Jeffrey S Wefel2,3
1Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Journal of neurological surgery. Part B, Skull base
|November 1, 2024
概括
患有鼻和鼻癌 (NPC) 的患者经常经历神经认知功能 (NCF) 障碍,特别是在记忆和学习方面. 放射治疗 (RT) 可以导致这些患者的记忆力进一步下降.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 心理学 心理学 心理学
背景情况:
- 在接受多模式治疗的鼻癌和鼻癌 (NPC) 患者中,关于神经认知功能 (NCF) 的研究有限.
- 了解基于疾病部位的NCF变化和差异对于患者护理至关重要.
研究的目的:
- 确定多模式治疗前后的NCF损伤率.
- 为了评估放射治疗 (RT) 后的NCF下降.
- 根据癌症疾病部位调查NCF的潜在差异.
主要方法:
- 对39名患有鼻腔和NPCs的患者进行了回顾性图表审查.
- 进行了全面的神经心理评估.
- 通过使用可靠的变化指数从前RT到后续评估来衡量下降.
主要成果:
- 最常见的基线障碍是口头记忆 (47%),学习 (43%),执行功能 (33%) 和口头流利 (22%).
- 在RT后的随访显示,主要是口头学习 (46%) 和记忆 (18%) 的下降.
- 人口/疾病变量与在RT前或后的NCF之间没有发现显著的关联.
结论:
- 患有鼻腔和NPC的患者容易产生基线NCF缺陷.
- 在这种患者群体中,在RT之后,记忆力下降是一个重大问题.
- 需要进一步的前性研究来探索治疗方式的影响和认知功能障碍的危险因素.
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