出生体重对纵向行为结果的性别特异性影响:使用多基因分数的孟德尔随机化方法
Lars Meinertz Byg1,2, Carol Wang1,2, John Attia1,3
1School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Biological psychiatry global open science
|November 1, 2024
概括
与出生体重 (BW) 相关的行为性差异是真实的. 较低的BW多基因分数 (PGS) 增加了男性的侵略性,但保护了女性,揭示了性别特异性的遗传效应.
科学领域:
- 行为遗传学行为遗传学
- 发展心理学是发展心理学.
- 人类遗传学 人类遗传学
背景情况:
- 之前关于出生体重 (BW) 和行为性差异的研究受到横截面设计和混因素的限制.
- 这些性别差异的真实性质需要使用先进的方法进行强有力的调查.
研究的目的:
- 为了确定与BW表型相关的性别差异是否可复制,使用孟德尔的随机化方法.
- 研究BW的多基因分数 (PGS) 与儿童和青少年的行为结果之间的关联.
主要方法:
- 利用了来自雷恩研究的数据,其中包括1484名基因型参与者和6446名儿童行为检查清单评估.
- 使用线性混合效应模型与BW-PGS来预测注意力,侵略性和社会问题,分析性别对基因型的相互作用.
- 使用教师评估和第二个PGS的验证结果,应用Bonferroni对显著性的纠正.
主要成果:
- 观察到一个显著的性别基因型相互作用:较低的BW-PGS与男性相比女性的侵略性增加相关.
- 结果在家长和教师评估中是一致的,表明了强度.
- 较低的BW-PGS在女性中显示出保护作用,而较低的BW表型在男性中显示出有害作用,这表明基因型与表型不匹配.
结论:
- 与出生体重相关的行为性差异是真实的,并受到性别特异性遗传决定因素的影响.
- 突出了遗传和环境因素对影响BW的行为影响的不同影响,以性别依赖的方式.
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