一个准实验性分析,比较COVID-19和非COVID-19病房的抗菌剂使用情况
Daniel Doyle1, Bruce Dalton2, Zuying Zhang3
1Department of Medicine, Cumming School of Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|November 1, 2024
概括
在COVID-19病房的抗菌药物使用 (AMU) 在大流行期间显著增加. 一套COVID-19订单影响了处方,在删除后,使用量下降.
科学领域:
- 传染性疾病 传染性疾病
- 医院 医院 药房 医院药房
- 公共卫生 公共卫生
背景情况:
- 新冠肺炎2019 (COVID-19) 疫情导致医疗保健实践发生了重大变化.
- 抗菌剂的使用 (AMU) 是医院获得的感染和抗菌素耐药性的关键因素.
- 了解大流行期间的AMU趋势对于优化抗菌药物管理至关重要.
研究的目的:
- 分析COVID-19大流行之前和期间的抗菌素使用 (AMU) 趋势.
- 为了比较COVID-19和非COVID-19病房之间的AMU.
- 为了调查COVID-19订单和AMU模式之间的关联.
主要方法:
- 采用了准实验性的,追溯的中断时间序列分析.
- 在1至4的疫情浪潮期间,从4家医院的5个COVID-19和4个非COVID-19病房收集了数据.
- 发病率比率 (IRR) 使用波松回归计算,以比较AMU率.
主要成果:
- 与所有系统性抗微生物药物的控制病房相比,在COVID-19病房观察到明显更高的AMU率.
- 特定的药物,如阿齐思罗米和 ceftriaxone 显示显著增加在COVID-19病房的使用.
- 在删除COVID-19订单后,这些药物的使用减少了两倍.
结论:
- COVID-19 流行病与抗微生物药物的使用增加有关,特别是在专门的 COVID-19 病房.
- 实施的COVID-19订单集显著影响了某些抗微生物药物的处方行为.
- 对临床决策支持工具进行重新评估和潜在的修改是有必要的,以优化AMU.
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