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相关概念视频

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

Bone Remodeling

38.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

3.1K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
3.1K
Endocrine Signaling01:45

Endocrine Signaling

64.0K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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相关实验视频

Updated: Jun 8, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

832

在骨中的雌激素信号传递.

Nuria Lara-Castillo1

  • 1Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri, 650 East 25th Street, Kansas City, MO 64110, USA.

Applied sciences (Basel, Switzerland)
|November 1, 2024
PubMed
概括
此摘要是机器生成的。

雌激素对骨健康至关重要,通过雌激素受体 (ERs) 影响生长,愈合和对机械压力的反应. 了解其复杂的信号传递至关重要,特别是在更年期后,以对抗骨质疏松症.

关键词:
骨质稳定性 骨质稳定性 骨质稳定性雌激素 雌激素 雌激素 是一种雌激素受体的受体是雌激素受体.

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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相关实验视频

Last Updated: Jun 8, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

832
Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K

科学领域:

  • 内分泌学 在内分泌学.
  • 骨生物学 骨生物学 骨生物学
  • 分子信号传输的方法

背景情况:

  • 雌激素对于维持整个生命的骨质稳定至关重要,影响骨生长,愈合和机械适应.
  • 雌激素通过各种受体起作用,包括雌激素受体α (ERα),雌激素受体β (ERβ) 和G蛋白结合雌激素受体1 (GPER1).
  • 雌激素信号与其他通路相互作用,有助于其广泛的骨效应,其缺乏,特别是绝经后,加速骨质损失和骨质疏松症.

研究的目的:

  • 为了提供一个更新的对雌激素在骨系统中的分子机制的审查.
  • 详细说明各种骨细胞中雌激素受体 (ER) 的表达模式.
  • 讨论与人类疾病相关的ER突变的最新发现以及雌激素信号在骨愈合中的作用.

主要方法:

  • 关于分子机制的文献综述.
  • 在骨细胞中分析ER表达数据.
  • 对ER突变和骨愈合的最新研究的综合.

主要成果:

  • 雌激素通过ERα,ERβ和GPER1.1调节骨质稳定.
  • 在不同的骨细胞类型中,ER表达有所不同.
  • ER突变可能导致骨病理,而雌激素信号传递对骨修复至关重要.

结论:

  • 对雌激素在骨健康中的作用的全面理解对于解决骨质疏松症和与年龄有关的骨质损失至关重要.
  • 对雌激素信号通路和ER功能的进一步研究是有必要的.
  • 向雌激素信号可能为骨疾病提供治疗策略.