传播和其他病原体的元分析:共感染或共检测? 这就是问题所在
Stefania Porcelli1, Pierre Lucien Deshuillers1, Sara Moutailler1
1ANSES, INRAE, Ecole Nationale Vétérinaire D'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700, Maisons-Alfort, France.
Current research in parasitology & vector-borne diseases
|November 1, 2024
概括
很少有研究证实了传播病原体的共同感染. 这次审查澄清了联合感染与联合检测/联合暴露,并敦促改善传播疾病的诊断和术语.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 携带的病原体经常一起发生,但区分真正的联合感染与联合检测或联合暴露是具有挑战性的.
- 准确的区分对于理解疾病动态和开发有效治疗方法至关重要.
研究的目的:
- 批判性地审查文献,并区分传播病原体共感染与共检测/共暴露的研究.
- 为共感染,共检测和共暴露提出明确的定义.
- 突出目前传播疾病的诊断方法的局限性.
主要方法:
- 426篇论文的基于文献的审查.
- 对报告携带病原体在人类和动物中同时出现的研究进行分析.
- 对诊断技术 (血清学,分子方法) 的评估.
主要成果:
- 在426篇审查的论文中,只有20篇提供了共同感染的直接证据.
- 当前的诊断方法经常误解联合检测/联合暴露为联合感染.
- 显著需要改进诊断策略和实验室模型.
结论:
- 准确的术语 (共同感染,共同检测,共同暴露) 对于准确的研究至关重要.
- 建议开发先进的诊断工具,包括的RNA测试.
- 需要使用动物模型进行进一步的研究,以了解病原体相互作用和进化.
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