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慢性缺血性中风中介细胞干细胞疗法-一个系统性审查

Mohammad Kurniawan^1,2, Yetty Ramli^1,2, Nadira Deanda Putri¹

¹Department of Neurology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.

Asian biomedicine : research, reviews and news

|November 1, 2024

概括

介质干细胞 (MSCs) 对慢性缺血性中风恢复有希望,早期研究表明安全性和有效性是积极的. 需要对更大的试验进行进一步的研究,以确认这些研究对中风患者的发现.

科学领域:

神经科学是一个神经科学.
再生医学是一种再生医学.
临床试验临床试验

背景情况:

缺血性中风是全球主要的健康问题,慢性病例的恢复选择有限 (中风后3个月以上).
介质细胞干细胞 (MSC) 是一种广泛研究的再生疗法,有可能用于中风康复.

研究的目的:

系统地审查和综合MSC治疗慢性缺血性中风患者的疗效和安全性的证据.
确定当前研究的局限性,并提出优化MSCs治疗的未来方向.

主要方法:

按照PRISMA指南进行系统审查.
在主要数据库 (PubMed,Google Scholar,CENTRAL,ClinicalTrials.gov) 进行全面的文献搜索.
从最初的70项研究中,包括4项符合预先定义的标准的研究.

主要成果:

观察到MSC治疗慢性缺血性中风患者的疗效和安全性的积极结果.
确定的局限性包括小样本大小,研究异质性和缺乏安慰剂对照.

结论:

目前的证据表明MSC治疗慢性缺血性中风的潜在益处,但需要更强有力的验证.
未来的研究应该专注于更大的,标准化的和比较性试验,以建立最佳的MSCs治疗方案.
进一步研究机制,施用途径和剂量对于推进MSCs疗法至关重要.

关键词:

慢性慢性慢性慢性缺血性中风中风介质细胞干细胞介质细胞干细胞一次性中风中风中风中风中风治疗治疗治疗治疗治疗治疗

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