基于预后营养指数和全身炎症指数及其应用的食道癌中急性辐射食道炎的预测模型
Lijun Wu1,2, Wen Li1, Xuanxuan Ma1
1School of Nursing, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
这项研究确定了食道癌患者急性辐射食道炎 (ARE) 的关键预测因子. 一个新的诺莫格拉姆模型准确地预测了ARE风险,有助于早期临床干预.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 医学统计 医学统计
背景情况:
- 急性辐射食道炎 (ARE) 是接受放射治疗的食道癌患者经常出现的并发症.
- 有效的风险预测模型对于在临床环境中管理ARE至关重要.
研究的目的:
- 在接受强度调节型合规放射治疗的食道癌患者中确定ARE的独立预测因子.
- 开发和验证一个用于预测ARE风险的名ogram模型.
主要方法:
- 在2018年1月至2022年12月期间接受治疗的225名食道癌患者的回顾性分析.
- 使用单变量和逻辑回归分析来确定风险因素.
- 使用决策曲线分析和校准曲线构建和验证了一个名ogram模型.
主要成果:
- 在225名患者中,有147人患有ARE.
- 预后营养指数,中性粒细胞与淋巴细胞的比率和血小板与淋巴细胞的比率被确定为ARE的独立预测因素.
- 开发的诺莫格拉姆模型表现出良好的校准性,可重现性和预测准确性.
结论:
- 预后营养指数,中性粒细胞与淋巴细胞的比率和血小板与淋巴细胞的比率是ARE的重要预测因素.
- 已建立的诺莫格拉姆模型作为一种有价值的工具,用于早期预测食道癌患者的ARE风险.
- 这个模型可以帮助临床医生制定个性化治疗策略和早期干预ARE.
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