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在急性髓性白血病中对联体受体对的表征:用于预后,治疗反应和T细胞功能障碍的评分模型

Chunlan Fu1, Di Qiu1, Mei Zhou1

  • 1Department of Hematology, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang, China.

Frontiers in oncology
|November 1, 2024
PubMed
概括

体受体相互作用会影响急性髓性白血病 (AML) 的进展. 一个新的LR.score模型预测AML预后,并指导个性化治疗,识别关键的AML特异性基因.

关键词:
在急性髓性白血病中,急性骨髓性白血病结合体受体的结合体受体一个T细胞细胞.预后 预后 预后治疗反应的治疗反应.

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相关概念视频

The Two-State Receptor Model01:29

The Two-State Receptor Model

The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with one...