唾液和皮肤微生物组可以成为与衰老相关的疾病的生物检测器吗? 目前的见解和未来的前景
Fahrul Nurkolis1, Trianna Wahyu Utami2, Aiman Idrus Alatas3
1Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, Indonesia.
Frontiers in aging
|November 1, 2024
概括
这项研究探讨了人类微生物组如何影响衰老和相关疾病. 维持微生物群的健康在一生中是预防与年龄相关的疾病和开发新治疗方法的关键.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 衰老的特点是生理功能下降和对疾病的易感性增加.
- 与年龄相关的疾病,包括心血管,肌肉骨和神经系统疾病,对全球死亡率做出了重大贡献.
- 由压力和与衰老相关的分泌表型 (SASP) 等因素驱动的细胞衰老和炎症是关键的衰老机制.
研究的目的:
- 审查当前对人类微生物组在衰老和与年龄有关的疾病中的作用的理解.
- 突出微生物组失生症与特定健康状况之间的联系.
- 探索针对微生物组的新型诊断和治疗与衰老相关疾病的策略的潜力.
主要方法:
- 对研究人类微生物群,衰老和相关疾病的文献综述.
- 分析生活方式,环境,遗传学和微生物组合在衰老中的相互作用.
- 检查微生物群落与与年龄相关的疾病 (如牙周炎,湿疹,阿尔茨海默氏症和帕金森病) 之间的联系.
主要成果:
- 微生物群的多样性受到与衰老相关的代谢和免疫变化的影响,影响疾病风险.
- 稳定的皮肤和口腔微生物对健康至关重要,而牙周病与牙周炎和湿疹等疾病有关.
- 口腔微生物与全身性疾病之间的相互作用是显而易见的,牙健康不佳与神经退行性疾病有关.
结论:
- 人类微生物组在健康和疾病中起着关键的,终身的作用,特别是在衰老中.
- 了解微生物组动态为开发与年龄相关疾病的创新诊断和治疗方法提供了有希望的途径.
- 维持整个生命周期的微生物群健康对于减轻衰老和相关病理的影响至关重要.
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