肠道微生物群和刺激性肠综合征:现状和前景
Xinyu Cheng1, Cheng Ren2, Xiaofei Mei1
1Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou, China.
Frontiers in medicine
|November 1, 2024
概括
肠道微生物群的改变与刺激性肠道综合征 (IBS) 的发展有关. 调节肠道细菌显示出有效的IBS治疗策略的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍的胃肠道疾病,严重影响患者的生活质量.
- IBS的病因在很大程度上是未知的,但新出现的证据表明肠道微生物群.
研究的目的:
- 审查和识别不同IBS亚型的肠道微生物群变化的共同点.
- 总结目前对肠道微生物群在IBS病原和治疗中的作用的理解.
主要方法:
- 关于研究IBS患者肠道微生物群的综合文献综述.
- 分析肠道微生物群多样性,丰富性和组成的变化.
- 针对肠道微生物群的拟议机制和治疗策略的综合.
主要成果:
- 与健康个体相比,IBS患者观察到肠道微生物群特征的持续变化.
- 肠道微生物群失调被证实是IBS发展的重要因素.
- 针对肠道微生物群的各种治疗模式已经显示出有前途.
结论:
- 肠道微生物群在IBS的病理生理学中起着关键作用.
- 调节肠道微生物群为管理IBS提供了相当大的治疗潜力.
- 需要进行进一步的大规模,多主题的临床研究,以标准化并推进IBS治疗.
相关概念视频
01:17Irritable Bowel Syndrome I: Introduction
251
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
251
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
144
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
144
01:17Chronic Bowel Disorders: Introduction
390
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
390
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
172
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
172
01:17Drugs for Treatment of Diarrhea-Predominant IBS
149
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
149
01:29Bacterial Flora of the Large Intestine
388
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
388