不要因为它而失眠:植入的脑电脑接口功能在晚期阿米托罗菲侧面硬化症中在夜间持续.
Sacha Leinders1, Erik J Aarnoutse1, Mariana P Branco1
1UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.
medRxiv : the preprint server for health sciences
|November 1, 2024
概括
这项研究表明,ALS患者可以在夜间可靠地使用脑电脑接口 (BCI). 一个专门的夜间模式解码器显著减少了意外激活,为那些严重受损的人提供了24 / 7通信.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复技术 康复技术 康复技术
背景情况:
- 大脑-计算机接口 (BCI) 为患有严重运动和言语障碍的个人提供通信解决方案,例如锁定综合征.
- 对于用户来说,BCI的持续24/7可用性至关重要,但夜间BCI使用的可行性在很大程度上仍未被探索.
- 这项研究的重点是使用基于电皮质谱的BCI对一个患有肌缩性侧面硬化症 (ALS) 的个体.
研究的目的:
- 为了研究在BCI控制中使用的神经信号特征 (低频和高频带功率) 的夜间动态.
- 评估在白天数据上训练的BCI解码器在应用到夜间数据时的性能.
- 开发和评估一个专门的"夜间模式"解码器,以便在睡眠期间可靠地拨打护理人员电话.
主要方法:
- 分析夜间低频带 (LFB) 和高频带 (HFB) 功率和变异的变化.
- 使用标准的白天解码器对夜间数据进行非故意BCI激活的量化.
- 开发和长期 (±1.5年) 的新型夜间模式BCI解码器的性能评估.
主要成果:
- 与白天相比,神经信号的强度和差异 (HFB和LFB) 在大多数夜晚显著更高.
- 日间解码器导致频繁的意外激活:每小时245次点击和13次护理人员电话.
- 开发的夜间模式解码器在79%的夜晚实现了无错的性能,每12个晚上只发生一次意外激活.
结论:
- 可靠的夜间BCI操作需要适应睡眠诱导的神经信号变化的解码器.
- 证明BCI夜间模式的长期有效性强调了24/7BCI可靠性对用户的关键重要性.
- 这项研究支持了高级神经疾病患者持续,不间断的沟通的潜力.
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