在严重抑郁症和健康志愿者中,在重复的负面思维过程中增加了岛屿功能连接
Landon S Edwards1, Saampras Ganesan2,3, Jolene Tay1
1Laureate Institute for Brain Research, Tulsa, OK, USA.
medRxiv : the preprint server for health sciences
|November 1, 2024
概括
重复的负面思维 (RNT) 在严重抑郁症 (MDD) 与大脑连接的改变有关. 这项研究揭示了在RNT期间岛屿子区域的超连接性,特别是涉及MDD患者的默认模式和突出网络.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 功能神经成像 功能神经成像
背景情况:
- 重复的负面思维 (RNT) 是主要抑郁障碍 (MDD) 的核心特征,其特点是持续关注负面自我经历.
- 以前的静止状态fMRI研究发现,胰岛和上突 (STS) 之间的功能连接 (FC) 对RNT强度至关重要.
- 了解与静止状态相比,在活动RNT期间岛屿FC模式如何变化,对于阐明抑郁症的神经基础至关重要.
研究的目的:
- 调查MDD和健康对照 (HC) 个体中静止状态和RNT诱导条件之间的岛屿功能连接 (FC) 模式的差异.
- 探索特征和状态RNT得分与MDD参与者的岛屿FC之间的关联.
主要方法:
- 在41名MDD患者和28名HC患者的休息状态和RNT诱导期间获得了功能磁共振成像 (fMRI) 扫描.
- 用双边岛屿子区域作为种子进行了种子对整个大脑的分析.
- 统计分析检查了诊断逐步运行相互作用效应和RNT得分与FC之间的相关性.
主要成果:
- 在岛屿次区域中没有发现显著的诊断-通过-运行相互作用效应.
- 与HC相比,MDD参与者在岛屿区域和小脑之间表现出更大的FC.
- 在RNT诱导过程中,两组患者在前/中胰岛和前额头,额头,后带带膜和中部部区域 (包括STS) 之间都显示出增加的FC.
- 在MDD中较高的特征-RNT与右岛和默认模式 (DMN) 和突出网络之间增加的FC有关.
- 较高的状态-RNT得分与岛屿区域,角性环和中性环的增加FC相关.
结论:
- 在活跃的RNT期间,岛屿子区域内的超连接性,特别是涉及DMN和突出网络,支持抑郁症中自我集中和负面情绪处理的理论.
- 这些发现突出了MDD中主动引起的RNT的神经基础,强调了岛屿电路在抑郁性反中的作用.
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