骨髓抑制在AML中的发生率高于ALL中的发生率
Wanling Chen1, Hongtao Wang1, Jiasheng Hu2
1Department of Clinical Medicine, Xiamen Medical College, Xiamen, Fujian 361023, P.R. China.
完整血清 (CBC) 参数可以帮助区分急性髓性白血病 (AML) 和急性淋巴细胞白血病 (ALL). 研究结果表明,白血病和泛细胞衰竭在AML中更常见,这表明正常血液形成的抑制更大.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 急性髓性白血病 (AML) 和急性淋巴细胞白血病 (ALL) 是不同的急性白血病亚型.
- 有限的研究存在于区分AML和ALL使用全血细胞计 (CBC) 参数.
研究的目的:
- 为了比较被诊断患有AML和ALL的中国患者之间的CBC参数.
- 调查M3 AML和非M3 AML亚型之间的差异.
- 确定急性白血病患者整体存活期的预后因素.
主要方法:
- 对147名新诊断的急性白血病患者 (儿童和成人) 的回顾性分析.
- 使用曼·惠特尼U和千平方测试进行的人口统计,CBC和临床随访数据的比较.
- 预后因素的估计,包括性别,年龄,白细胞计数和血红蛋白.
主要成果:
- 与ALL患者相比,AML患者的白血病,贫血性白血病,血小板缩性白血病和全细胞缩性白血病的发生率明显高 (P<0.05).
- 贫血是所有患者整体生存的有利预后因素 (HR=0.185,P=0.018).
- 在AML中,正常的造血似乎比ALL更受抑制.
结论:
- CBC参数,如白血病和泛细胞衰竭,可以帮助区分AML和ALL.
- 患有急性白血病的患者表现出白血病,泛细胞衰竭或联合细胞衰竭可能更有可能患有AML.
- 这些发现强调了CBC在急性白血病亚型的早期分化中的实用性.
更多相关视频
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
相关概念视频
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Differentiation of Common Myeloid Progenitor Cells
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
