语言网络老化良好:在老大脑中保留了选择性,横向化和网络内部的功能同步
Anne Billot1,2, Niharika Jhingan3,4, Maria Varkanitsa5
1Department of Neurology, Massachusetts General Hospital & Harvard Medical School; Boston, MA 02114.
bioRxiv : the preprint server for biology
|November 1, 2024
概括
老年人表现出执行功能和相关的多重需求 (MD) 网络的显著下降. 然而,他们的语言网络仍然非常完善,像年轻成年人一样运作.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 衰老研究研究 衰老研究
背景情况:
- 健康的衰老涉及到大脑的变化,但像执行功能这样的认知能力下降,而语言处理仍然保留.
- 这种认知异质性表明大脑网络之间存在不同的衰老模式.
研究的目的:
- 通过功能磁共振成像 (fMRI) 来研究语言选择性网络和多重需求 (MD) 网络的与年龄相关的变化.
- 为了比较老年人与年轻对照者的大脑网络功能和连接性.
主要方法:
- 利用个体主体fMRI分析 ("精确fMRI") 来检查语言网络和MD网络.
- 在执行功能和语言任务期间,比较了老年人 (n=77) 和年轻对照人 (n=470) 的激活模式,空间范围和功能同步.
主要成果:
- 与年轻人相比,老年人表现出较弱,空间范围较小的MD网络激活和网络内同步减少.
- 老年人的语言网络显示保持了激活强度,选择性,横向化和内部同步,看起来与年轻人无法区分.
结论:
- 某些大脑网络,如语言网络,可以在老年时保持"年轻"的功能和连接性,尽管总体上与衰老相关的大脑变化.
- 这些发现支持在衰老过程中保存语言技能的行为观察,并突出了特定网络的衰老轨迹.
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