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Updated: Jun 8, 2025

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内源神经元DNA双链断裂不足以驱动大脑衰老和神经退行

Sarah Cohen, Laura Cheradame, Karishma J B Pratt

    bioRxiv : the preprint server for biology
    |November 1, 2024
    PubMed
    概括

    神经元中自发的DNA双链断裂 (DSB) 不会导致大脑衰老或神经退行,即使主要的修复途径,即经典非同源端结合 (C-NHEJ) 被禁用. 神经元的DSB积累不足以驱动衰老的表型.

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