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Updated: Jun 8, 2025

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
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Published on: December 2, 2022

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拓皮索马酶1活性的表观遗传控制呈现出癌症脆弱性

Tae-Hee Lee1, Colina X Qiao1,2, Vladislav Kuzin3

  • 1Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287.

bioRxiv : the preprint server for biology
|November 1, 2024
PubMed
概括

基因组变体 macroH2A1.1 通过协调拓酶1分裂综合体 (TOP1cc) 解析来保护基因组免受DNA损伤. 它的替代拼接调节了这一过程,影响了TOP1抑制剂治疗期间的癌症脆弱性和患者存活率.

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DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
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X-chromosome...
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