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什么时候信任表观遗传钟:避免错误的阳性在衰老干预.

Daniel S Borrus1, Raghav Sehgal2, Jenel Fraij Armstrong2

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概括

新的表观遗传钟,训练在死亡率上,可靠地跟踪衰老干预措施. 经过时间学年龄训练的旧时钟通常会产生错误的阳性结果,这表明需要重新评估已发表的研究结果.

关键词:
年龄的逆转.老龄化干预措施的使用.生物标志物 生物标志物遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表有错误的阳性结果.

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科学领域:

  • 生物遗传学 生物遗传学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 生物标志物发现发现

背景情况:

  • 老龄化干预措施旨在降低发病率和死亡率风险.
  • 基于DNA甲基化的表观遗传时钟用于测量干预对健康的影响.
  • 不同的表观遗传钟之间存在差异,可能导致假阳性结果.

研究的目的:

  • 评估流行表观遗传钟在测量衰老干预措施中的可靠性.
  • 为了比较不同的表观遗传时钟代和训练方法的性能.
  • 为未来的临床试验确定强大的表观遗传钟.

主要方法:

  • 评估了6个流行的表观遗传钟,使用纵向数据集与衰老干预措施或衰老加速事件.
  • 与高测试-重新测试可靠性版本的标准钟进行比较.
  • 分析了不同数据集和时钟类型的时钟变化和可复制性.

主要成果:

  • 对死亡率或衰老速度进行训练的表观遗传钟在多个钟和可靠性版本中显示出可靠的效果.
  • 在时间学年龄上训练的钟表经常产生零星的,不可复制的变化,可能是错误的阳性.
  • 经过多次测试校正后,结果保持一致,突显了基于死亡率的时钟的可靠性.

结论:

  • 新一代表观遗传钟,特别是那些对死亡率进行训练的表观遗传钟,对于测量衰老干预措施来说更可靠.
  • 基于年代的时间表可能会产生不可靠的结果,需要在已发表的文献中重新检查.
  • 这项研究为在临床试验中选择适当的表观遗传钟为衰老研究提供了基础.