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Updated: Jun 8, 2025

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Published on: November 30, 2017

在电刺激过程中,子V1的局部场势的层特异动态

Sangjun Lee, Zhihe Zhao, Ivan Alekseichuk

bioRxiv : the preprint server for biology

|November 1, 2024

概括

电脑刺激有选择性地影响哺乳动物新皮层的更深层. 这项研究揭示了神经活动的相位依赖性变化,这对于有针对性的神经调节策略至关重要.

科学领域:

神经科学是一个神经科学.
计算神经科学是一种神经科学.
系统神经科学系统神经科学

背景情况:

哺乳动物新皮质有六个不同的细胞层,对于感官处理至关重要.
在研究神经活动方面,局部场电位 (LFP) 的层状记录至关重要.
电脑刺激对LFPs的层特异性影响尚不清楚.

研究的目的:

研究电刺激对初级视觉皮层中LFPs的层特异性影响.
了解电刺激如何调节不同皮层中的神经活动.

主要方法:

在视觉刺激期间在子初级视觉皮层进行了层状LFP记录.
将低频正弦形电流应用于叶.
分析了与电刺激阶段相关的视觉唤起的潜能.

主要成果:

更深层的皮质层表现出LFP组件的相位依赖变化,以应对电流.
表面皮层没有显示显著的相位依赖调制.
一个皮层柱模型支持了这些发现,将它们归因于更深层神经元驱动力.

结论:

电刺激可以选择性地调节更深层的皮质层.
通过了解层特异性反应,研究结果提供了针对性神经调节的见解.
这项研究推动了精确的大脑刺激技术的发展.

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相关概念视频

Action Potential

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...