运动皮层投射的选择性扩张在声乐新性的演变中
Emily C Isko1,2, Clifford E Harpole1, Xiaoyue Mike Zheng1,2
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
bioRxiv : the preprint server for biology
|November 1, 2024
概括
研究人员研究了小鼠大脑结构和发声的演变. 他们发现,在唱歌的小鼠中,特定的大脑区域的扩张与其先进的声乐能力相关,为声乐进化提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 进化生物学 进化生物学
- 比较解剖学的比较解剖学
背景情况:
- 了解大脑结构的演变及其与行为创新的联系是一个关键的挑战.
- 与实验室老鼠 (Mus musculus) 相比,阿尔斯顿的歌唱老鼠 (Scotinomys teguina) 表现出独特的声音行为.
研究的目的:
- 用阿尔斯顿的唱歌小鼠作为模型,量化测试运动皮层进化的模型.
- 为了研究哺乳动物声乐行为演化的神经基础.
主要方法:
- 使用了批量追踪,串行二光子断层扫描和高通量DNA测序.
- 分析了超过76,000个条形码的面部或面部运动皮层 (OMC) 神经元的投影模式.
主要成果:
- 在唱歌的小鼠中发现OMC投射到听觉皮层区域 (AudR) 和中脑周水道灰色 (PAG) 的200%扩展.
- 在唱歌小鼠中确定了独家OMC预测向AudR的优惠扩展.
- 众所周知,这些区域都参与了声乐行为.
结论:
- 祖先的运动皮层投影的选择性扩张可以在短的进化时间尺度上驱动行为分歧.
- 建议增强皮层对发声的控制的进化机制,可能预先适应人类语言.
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