可分离的默认模式 网络连接模式 在精神病风险中的不同症状的基础上
Chelsea C Ajunwa1, Jiahe Zhang1, Guusje Collin2,3,4
1Department of Psychology, Northeastern University, Boston, MA.
bioRxiv : the preprint server for biology
|November 1, 2024
概括
临床高风险 (CHR) 个体表现出高度的默认模式网络 (DMN) 连接,将特定的DMN途径与早期精神病中的焦虑和负面症状联系起来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 临床高风险 (CHR) 阶段是精神病发作之前的,其特点是下值症状和功能衰退.
- 在精神分裂症中注意到默认模式网络 (DMN) 超连接性,但其在CHR阶段和跨诊断症状中的作用尚不清楚.
研究的目的:
- 在CHR个体中调查DMN功能连接.
- 确定CHR中DMN超连接是否与特定的症状尺寸有关.
主要方法:
- 分析了来自251名年轻成年人的休息状态fMRI数据 (158名CHR,93名对照).
- 整个大脑的种子到声细胞分析使用中部前额叶皮质 (MPFC) 作为种子.
- 研究了DMN连接和症状严重程度 (负面,积极,情感) 之间的相关性.
主要成果:
- 与对照人群相比,CHR个体与DMN节点 (PCC) 和听觉皮层 (STG/MTG) 的MPFC连接性显著增加.
- 与焦虑症状相关的MPFC-PCC连接 (r=0.23,p=0.006).
- MPFC-STG/MTG连接与负症状严重程度相关 (r=0.26,p=0.001).
结论:
- 在CHR阶段,DMN超连接的明显模式存在.
- 这些可分离的DMN超连接模式可能支特定的症状维度,如焦虑和负面症状.
相关概念视频
Dissociative Identity Disorder
30
Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
30
Dissociative Disorders
32
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
32
Psychological and Sociocultural Causes of Schizophrenia
80
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
80
Personality Disorders: Paranoid and Schizoid
31
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Paranoid Personality Disorder
Paranoid personality disorder is...
31
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
479
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
479
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
63
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
63


