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Updated: Jun 17, 2026

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了解人类结肠上皮细胞中与疾病相关的代谢变化,使用ColonEpithelium代谢重建

Boyu Jiang, Nick Quinn-Bohmann, Christian Diener

    bioRxiv : the preprint server for biology
    |November 1, 2024
    PubMed
    概括

    研究人员开发了人类结肠上皮细胞的第一个基因组规模代谢模型 (GEM),iColonEpithelium. 该模型有助于理解宿主微生物群相互作用,并识别炎症性肠病中的代谢特征.

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    Renewal of Intestinal Stem Cells01:23

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    The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...