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Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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相关实验视频

Updated: Jun 8, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

嗅觉组合编码支持C的风险回报决策. 伊莱根斯 (elegans) 是一个词.

Md Zubayer Hossain Saad, William G Ryan V, Chelyan A Edwards

bioRxiv : the preprint server for biology

|November 1, 2024

概括

动物的生存取决于嗅觉行为. 这项研究揭示了线虫C. elegans如何整合相反的感官输入来调节运动和导航其环境,展示了嗅觉编码的新机制.

科学领域:

神经科学是一个神经科学.
动物行为动物行为
感官系统感官系统

背景情况:

嗅觉驱动的行为对于动物的生存至关重要.
嗅觉输入解码背后的机制尚未完全理解.
线虫C. elegans是研究神经回路的模型生物.

研究的目的:

为了研究C. elegans的嗅觉编码机制.
了解嗅觉输入是如何集中集成的.
为了确定集成信号如何调节行为反应.

主要方法:

整个网络 (Ca++) 图像使用.
分析了C. elegans对气味剂1-octanol的反应.
监测了运动逆转和速度,以评估行为输出.

主要成果:

气味剂1-octanol在外围被组合编码为吸引力和排斥力的信号.
这些对立的输入的中央集成调节行为敏感性和价值.
这些通路的平衡调节了运动运动指令内部神经元,控制反转.

结论:

更多相关视频

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons

Published on: September 7, 2017

A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

Published on: December 22, 2012

相关实验视频

Last Updated: Jun 8, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons

Using an Adapted Microfluidic Olfactory Chip for the Imaging of Neuronal Activity in Response to Pheromones in Male C. Elegans Head Neurons

Published on: September 7, 2017

A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

Published on: December 22, 2012

一个单一的气味剂可以激活具有相反价值的通路,突出显示了输入集成的重要性.
这种整合起到了监管节点的作用,允许C. elegans权衡环境机会和危险.
这些发现为嗅觉系统的感知,反应调制和神经可塑性提供了洞察力.