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Updated: Jun 8, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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E3 Ubiquitin Ligase Trip12在造血干细胞发育过程中减弱了Wnt9a/Fzd9b信号传递

Jessica Ensing1, Amber D Ide1, Carla Gilliland1

  • 1Department of Cell Biology, Van Andel Institute, Grand Rapids, Michigan, 49503, USA RRID: SCR_021956.

bioRxiv : the preprint server for biology
|November 1, 2024
PubMed
概括

甲状腺激素受体相互作用体12 (Trip12) 针对Frizzled 9b (Fzd9b) 进行降解,调节Wnt9a/Fzd9b信号传输. 这种机制控制了斑马鱼的造血干细胞增殖.

关键词:
在 Fzd Fzd 里面.在FZD9bb.旅行12 旅行12他们不想做.没有信号发送.没有Wnt9a.造血干细胞是血液形成的干细胞.在任何地方都是无处不在的.

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