Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

6.0K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
6.0K
The Retina01:32

The Retina

67.8K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
67.8K
Vision01:24

Vision

52.9K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
52.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Melanopsin regulates axonal translation underlying retinohypothalamic circuit assembly.

bioRxiv : the preprint server for biology·2026
Same author

Eye-specific differences in active zone addition during synaptic competition in the developing visual system.

eLife·2025
Same author

Microanalytical Mass Spectrometry with Super-Resolution Microscopy Reveals a Proteome Transition During Development of the Brain's Circadian Pacemaker.

Analytical chemistry·2023
Same author

Volumetric super-resolution imaging by serial ultrasectioning and stochastic optical reconstruction microscopy in mouse neural tissue.

STAR protocols·2021
Same author

Correcting Artifacts in Single Molecule Localization Microscopy Analysis Arising from Pixel Quantum Efficiency Differences in sCMOS Cameras.

Scientific reports·2019

相关实验视频

Updated: Jun 8, 2025

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
13:13

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Published on: March 19, 2021

2.8K

活动依赖的突触集群是眼睛特异性竞争的基础,在正在发展的视网原蛋白系中.

Chenghang Zhang1, Tarlan Vatan1, Colenso M Speer1

  • 1Department of Biology, University of Maryland, College Park, Maryland, USA. 20742.

bioRxiv : the preprint server for biology
|November 1, 2024
PubMed
概括

在发育早期,自发的视网膜活动会在视觉系统中形成眼睛特有的突触集群. 这种活动依赖的过程对于在视觉体验开始之前在大脑中形成功能连接至关重要.

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 视觉系统研究 视觉系统研究

背景情况:

  • 协同活跃的突触在空间上聚集在一起,以支持学习,记忆和感官处理的本地计算.
  • 在哺乳动物的视觉系统中,视网膜质细胞 (RGC) 轴突在背侧生殖核 (dLGN) 中形成集群输入,用于信号集成.
  • 众所周知,视觉体验在眼睛打开后促进突触聚类,但视觉前体验机制尚不清楚.

研究的目的:

  • 调查视觉体验之前的视网质突触集群形成的最早事件.
  • 为了确定在早期视觉系统发育期间,突触聚类是否是眼睛特异性的和活动依赖的.

主要方法:

  • 使用体积超分辨率单分子定位显微镜.
  • 在小鼠中使用了眼睛特异性标记,用于发育视网膜原蛋白突触.
  • 在对照和突变小鼠中分析了突触结构和聚类模式,这些小鼠具有破坏自发的视网膜活动.

主要成果:

  • 证明在出生后的第一个星期内,突触聚类是眼睛特异的和活动依赖的.
  • 识别了具有多个活跃区域的视网膜质突触,周围环绕着类似眼睛的突触,缺乏对立眼睛的输入.
  • 观察到,破坏自发的视网膜波动活动阻止了突触聚类,即使多活性区域突触形成.

更多相关视频

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

6.1K
Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System
09:00

Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System

Published on: February 11, 2022

3.8K

相关实验视频

Last Updated: Jun 8, 2025

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
13:13

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Published on: March 19, 2021

2.8K
Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

6.1K
Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System
09:00

Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System

Published on: February 11, 2022

3.8K

结论:

  • 自发的视网膜活动在视网膜原蛋白精细化过程中,在调节眼睛特异性突触集群方面发挥着至关重要的作用.
  • 这种活动依赖的聚类发生在视觉体验之前,对于组织视觉电路至关重要.
  • 这些发现突出了建立对感知和行为至关重要的功能视觉通路的机制.