2型糖尿病重塑了附带循环,并在缺血性中风后促进白细胞粘附
Yoshimichi Sato1,2,3, Yuandong Li4, Yuya Kato1,2,3
1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
bioRxiv : the preprint server for biology
|November 1, 2024
概括
2型糖尿病 (T2DM) 损害了附带血液循环,并加剧了中风的结果. 在T2DM小鼠中,中风导致持续的血流减少和白细胞粘附增加,突出炎症.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2DM) 与中风的不良后果有关,这是由于左脑关节附带补偿受损.
- 脑卒中后的中性粒细胞-内皮细胞相互作用可以降低血液流动速度,但T2DM的具体影响仍然不清楚.
研究的目的:
- 确定中风后T2DM中附带循环和白细胞-内皮相互作用的时间和空间变化.
- 调查T2DM对中脑动脉 (MCA) 中风后健康血管改造和血液流动动力学的影响.
主要方法:
- 在清醒控制和T2DM小鼠中利用双光子显微镜观察健康动脉和静脉.
- 分析了MCA中风后的血流速度,血管尺寸和白细胞-内皮质粘附动态.
主要成果:
- 与对照组相比,T2DM小鼠表现出较小的海皮容器和较低的基线流速.
- 在中风后,T2DM小鼠显示动脉和静脉血流持续减少,微血管流恢复受损,白细胞粘附增加.
- 在T2DM小鼠中,在中风后观察到中性粒细胞透到大脑外围膜的增加.
结论:
- T2DM通过损伤的附带循环和增加的炎症加剧了与中风相关的血液动力学缺陷.
- 与T2DM相关的慢性炎症可能会导致血管重塑,并导致中风的不良结果.
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