大脑功能连接和认知衰老的时间变化的特征与年龄相关的差异
Furong Yao1, Ziyang Zhao1, Yin Wang1
1Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering, Lanzhou University, Lanzhou, Gansu, China.
Psychophysiology
|November 1, 2024
概括
大脑的模块化组织随着年龄的增长而动态变化. 协会网络和特定网络过渡的更高变化与认知功能相关,揭示了老化大脑的动态.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 网络科学 网络科学
背景情况:
- 大脑的功能组织在整个生命周期中不断发展.
- 动态,时间变化的大脑连接提供了比静态措施更深入的见解.
- 模块化大脑结构的与年龄相关的变化仍然在很大程度上未被探索.
研究的目的:
- 研究大脑中与年龄相关的动态模块重构.
- 分析模块化大脑网络结构在成年人一生中如何变化.
- 探索动态模块化与衰老中的认知表现之间的关系.
主要方法:
- 利用来自Cam-CAN数据集的615名参与者 (18-88岁) 的休息状态功能性MRI数据.
- 应用基于图形的模块化分析来评估模块化可变性和节点过渡.
- 研究了模块化大脑网络动态中的与年龄相关的线性和非线性趋势.
主要成果:
- 模块化大脑结构显示了与年龄相关的显著线性和非线性变化.
- 在成年早期和晚期,模块变异性升高,特别是在协会网络中.
- 背部注意网络的转换率比其他网络的转换率最高.
- 动态模块化与认知组件和记忆性能相关联.
结论:
- 衰老显著影响大规模大脑网络的动态模块化组织.
- 动态模块化大脑特征与衰老期间的认知灵活性和记忆有关.
- 研究结果支持将脱差和补偿作为与年龄相关的功能性大脑相互作用的结果.
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