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塞图西马布 scFv-修饰的5-FU装载奇托桑纳米颗粒:"一个新的治疗平台

Masumeh Jalalvand¹, Fariba Esmaeili², Khadijeh Falahzadeh¹

¹Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Current pharmaceutical biotechnology

|November 1, 2024

概括

一个新的纳米粒子传递系统,scFv-CS/5-FU NPs,有效地准结直肠癌细胞. 这种有针对性的方法提高了化疗的疗效,并降低了所需的5-FU剂量,最大限度地减少了副作用.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

结肠直肠癌 (CRC) 仍然是癌症死亡的主要原因.
开发有针对性的输送系统对于改善CRC治疗结果至关重要.
西马布单链断片变量 (scFv) 抗体碎片与5甲 (5-FU) 封装的奇托桑纳米粒子 (CS NPs) 结合,以创建scFv-CS/5-FU NPs.

研究的目的:

开发和描述用于结直肠癌治疗的活性向纳米粒子系统.
评估新型scFv-CS/5-FUNP的疗效和毒性.
评估该系统在减少化疗副作用方面的潜力.

主要方法:

使用流体系统合成了封装5-甲 (5-FU) 的素纳米粒子 (CS NPs).
重组scFv抗体碎片与CS/5-FUNP的表面结合.
评估了HCT116细胞的物理化学特性,药物释放,以及体外细胞毒性 (MTT测定) 和亡诱导 (流细胞计).

主要成果:

合成的CS/5-FUNP表现出同质的球形形状和可持续的药物释放.
scFv-CS/5-FU NPs是球形的,并显示了癌细胞活力的显著剂量依赖性减少.
向的纳米颗粒在97.97%的HCT116细胞中诱导了亡.

结论:

开发的scFv-CS/5-FUNP显示出显著的抗结直肠癌活性.
这种新的有针对性的输送系统有效地降低了所需的5-FU剂量.
这些发现突出了scFv-CS/5-FUNP的潜力,通过尽量减少破坏性的副作用来改善化疗.

关键词:

5-FU的使用情况.积极准交付系统的交付系统这种药物是Cetuximab.基托桑是一种酸盐.大肠直肠癌 (CRC) 是一种癌症.scFvv 在线阅读

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