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Updated: Jun 8, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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假设蛋白质的功能冗余和双重功能在欧尼塞兰类型二类生物合成中的作用

Ayesha Ahmed Chaudhri1,2, Yuya Kakumu1,2, Sirinthra Thiengmag1,2

  • 1Institute for Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt am Main, Germany.

ACS chemical biology
|November 1, 2024
PubMed
概括

研究人员发现了来自actinobacteria的新复杂的二聚类,称为euthailols. 这些化合物是由一个不寻常的基因集群产生的,显示出抗微生物药物对抗格兰氏阴性病原体的潜力.

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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli10:41

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Protein Complexes with Interchangeable Parts

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Biosynthesis in Bacteria

Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
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