与COVID-19相关的病理的谱系是什么?
Ankita Muthya1, Elif I Ekinci1,2, Ashani Lecamwasam1,2,3
1Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Internal medicine journal
|November 1, 2024
概括
病在住院的冠状病毒病2019 (COVID-19) 患者中很常见,经常导致严重疾病. 与特定遗传因素相关的急性管状缩和崩性球病变是观察到的最常见的病理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- 在2019年冠状病毒病 (COVID-19) 住院治疗中,脏干扰是常见的.
- 与COVID-19相关的病与疾病严重程度,发病率和死亡率的增加有关.
- 了解特定的病理对于患者管理至关重要.
研究的目的:
- 系统地审查和概述COVID-19患者病理的范围.
- 为了确定COVID-19患者不同损伤的患病率和特征.
主要方法:
- 对Medline OVID和Scopus数据库的系统文献审查.
- 包括病例报告,病例系列,队列研究和COVID-19患者进行脏活检的解剖研究.
- 分析了2020年8月至2021年11月期间发表的包括159名患者的14项研究.
主要成果:
- 最常见的病态是急性管状缩 (40.1%) 和缩性结核病 (28.9%).
- 在患有高危阿波利波蛋白L1基因型 (44/46) 的非洲血统患者中,主要观察到缩性淋巴细胞病变 (44/46).
- 其他不太常见的淋巴细胞疾病包括膜性病,二次FSGS,最小变化疾病和初级FSGS.
结论:
- 在COVID-19中,急性损伤是多因素的,急性管状缩是最常见的原因.
- 缩性淋巴细胞病变是COVID-19中显著的淋巴细胞损伤,与阿波利波蛋白L1基因型密切相关.
- 需要进一步研究COVID-19对脏健康的纵向影响,以指导治疗和预防慢性脏病的进展.
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