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Updated: Jun 8, 2025

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与体细胞得分相关的SNP是否适合作为荷尔斯坦牛对特定乳腺炎病原体敏感性的标记?

U Müller1, E M Strucken1, J Gao1

  • 1Breeding Biology and Molecular Genetics, Department for Crop and Animal Sciences, Humboldt-Universität Zu Berlin, Berlin, Germany.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
|November 1, 2024
PubMed
概括

这项研究调查了与霍尔斯坦牛乳腺炎病原体相关的单核酸多态 (SNP). 六个SNP与埃斯库林阳性链球菌,凝结酶阴性葡萄球菌和大肠杆菌的存在有关,有可能改善疾病耐药性.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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