大脑微观结构的纵向演变在扩散皮质症成像的肝硬化患者中
Yuan-Yuan Chen1, Zi-Ning Lu2,3, Qi Zhang4
1Tianjin International Joint Research Center for Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Journal of magnetic resonance imaging : JMRI
|November 1, 2024
概括
扩散性皮质损伤成像 (DKI) 揭示了肝硬化患者肝移植前后的纵向大脑微观结构变化. 这些微观结构的变化,特别是在放射性皮质变化中,可能与移植后的认知功能相关.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是指放射学
- 医学物理 医学物理
背景情况:
- 肝移植可以改善认知功能,但肝硬化患者肝移植前后的纵向大脑结构变化尚未得到充分研究.
- 肝硬化会影响大脑结构,需要对其进展和干预后解决方案进行详细的调查.
研究的目的:
- 通过扩散曲解成像 (DKI) 来研究肝硬化患者大脑微观结构的纵向变化.
- 在肝硬化患者肝移植前后评估大脑组织特征的变化.
主要方法:
- 一项前性研究,涉及153名肝硬化患者 (有和没有肝脏脑病) 和93名健康对照.
- 使用3.0T扫描仪使用扩散皮质图像 (DKI) 来评估大脑微观结构.
- 统计分析包括voxel-wise ANOVA和线性混合效应模型,以纵向评估扩散指标.
主要成果:
- 与对照组相比,肝硬化患者在前带皮层的放射性皮质 (RK) 显著减少.
- 移植后,白骨中的RK呈上升趋势,而右侧中后回形中的RK呈下降趋势.
- 在肝移植后,在上方纵向囊中观察到RK的新发病下降.
结论:
- 纵向DKI指标有效地跟踪肝硬化患者肝移植前后的大脑微结构变化.
- 观察到的微观结构变化可能与肝移植手术后的认知改变有关.
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