改善的血管健康与增加的体力活动水平和减少在类风湿性关节炎中久坐的行为有关
K Meireles1,2, T Peçanha1,2,3, A J Pinto1,2,4
1Applied Physiology and Nutrition Research Group-School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de São Paulo, Sao Paulo, Brazil.
American journal of physiology. Heart and circulatory physiology
|November 1, 2024
概括
减少久坐时间和增加轻量体育活动与类风湿性关节炎 (RA) 患者的血管健康改善有关. 即使是轻微的活动也有利于血管直径,而长时间坐着会损害血管直径.
科学领域:
- 类风湿病学 类风湿病学
- 心血管健康 心血管健康
- 运动生理学 运动生理学
背景情况:
- 类风湿性关节炎 (RA) 与血管健康不佳和心血管风险升高有关.
- 身体活动 (PA) 建议在RA中管理心血管健康,但客观PA测量的证据有限.
- 了解特定的体力活动行为和血管标志物之间的关系对于RA管理至关重要.
研究的目的:
- 调查客观测量的体力活动 (PA) 和静坐行为 (SB) 与 RA 的绝经后妇女血管健康标志物之间的关联.
- 为了确定PA和SB的不同强度和持续时间是否与手臂动脉 (BA) 和表面大腿动脉 (SFA) 的直径和动脉内心介质厚度有关.
主要方法:
- 一项涉及82名患有RA的绝经后妇女的横截面研究.
- 血管评估包括超声波测量BA和SFA流介导扩张,基线和后高血压直径,以及动脉内膜-介质厚度.
- 一个为期7天的加速度计评估量化了PA (轻度,中度至强度,步行,站立) 和SB (总时间,长时间的发作).
主要成果:
- 长时间的SB (>60分钟发作) 和总久坐时间与BA基线和峰值直径相反相关.
- 总的静坐时间也与峰值SFA直径有负相关性.
- 光强度PA和步进时间与BA基线和峰直径有关,而站立时间与增加的SFA峰直径相关.
- 在中度至强度的PA和血管结局之间没有发现显著的关联.
结论:
- 在RA患者中,久坐不动的行为与手臂动脉和表面大腿动脉直径有负相关,而光强度的体力活动与手臂动脉和表面大腿动脉直径有正相关.
- 这些发现强调了减少久坐时间和增加身体活动的重要性,即使在光强度下,也可能改善 RA 血管健康.
- 针对SB减少和RA中PA促进的干预措施的进一步研究对于心血管风险管理是有必要的.
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