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Updated: Jun 8, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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PI3K酶的ATP竞争性抑制剂通过控制膜结合来表现出异形选择性双重作用

Grace Q Gong1,2, Glenn R Masson3, Woo-Jeong Lee1

  • 1Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.

The Biochemical journal
|November 1, 2024
PubMed
概括

这项研究表明,ATP位点抑制剂阻断增长因子激活的PI3Kα膜相互作用. 然而,瘤基因突变可以使这种相互作用对这些抑制剂不敏感,突出复杂的PI3Kα调节.

关键词:
这就是PIK3CA.脂类激酶酶是一种脂类激酶.膜蛋白质是膜蛋白质的组成部分.氏酸3-酶酶的使用方法蛋白质构成的结构.小分子的小分子.

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